Vol.100 No.8 contentsPRACTICA OTO-RHINO-LARYNGOLOGICA
Vol. 100 No. 8 August 2007
A Case of Reversible Posterior Leukoencephalopathy Syndrome which Developed during Chemoradiotherapy for Head and Neck Cancer:
the Involvement of Bacterial Translocation was Considered
Shinya Tachibana, Hajime Terao and Takeyuki Sanbe
(Showa University Fujigaoka Hospital)
Masahiro Katsuno
(Odawara City Hospital)
Hideki Takemura
(Yokohama Rosai Hospital)
Combination therapy such as chemotherapy and radiotherapy is often chosen, depending on the case, for head and neck cancer in view of the preservation of potency. However, on the other hand, it is necessary to note the onset of therapeutic side effects.
The patient was a 35-year-old woman. During chemoradiotherapy for mesopharyngeal carcinoma, she suddenly developed shock and multiple organ failure, requiring intensive treatment. She also developed reversible central nerve symptoms during the course.
The involvement of bacterial translocation was thought to be the cause of shock, and the reversible central nerve symptoms were considered to be a pathological condition, known as reversible posterior leukoencephalopathy syndrome. We discuss these conditions on the basis of the clinical features, and the process that led to diagnosis in this case.
Key words : reversible posterior leukoencephalopathy syndrome (RPLS), chemoradiotherapy, bacterial translocation