Vol.101 No.4 contentsPRACTICA OTO-RHINO-LARYNGOLOGICA
Vol. 101 No. 4 April 2008
Clinical Results of Alternating Chemoradiotherapy
for Nasopharyngeal Cancer
Atsushi Yuta, Yoshihito Nomoto, Shinobu Arima, Kazuya Otsu,
Hajime Ishinaga, Tetsu Nakamura, Kazuhiko Takeuchi, Yasufumi Yamashita,
Noriko Ii and Yuichi Majima
(Mie University Graduate School of Medicine)
Twenty-six patients with nasopharyngeal cancer treated at Mie University Hospital between 1996 and 2005 were reviewed. The subjects consisted of 18 males and 8 females. The average age was 53.9-years-old. The clinical stage was IIA in 1, IIB in 4, III in 9, IVA in 7, IVB in 2 and IVC in 3. Histological classification by WHO was type I in 5, type II in 17 and type III in 4. Scheduled courses of alternating chemoradiotherapy were planned. A total 30.6-36 Gy (1.8-2.0 Gy five times per week) was administered between the skull base and supraclavicular fossa. An additional total 26-30 Gy was administered over a decreased irradiation field. A total of 3 courses of chemotherapy were also administered. Each course of radiotherapy or chemotherapy was administered alternatively. Alternating chemoradiotherapy were administered in 21 of 26 cases. Of these 21 cases, poor prognoses were predicted in 2 cases demonstrating distant multiple metastases, 2 cases demonstrating invasion of the clivus, and one case demonstrating intracranial invasion. The other 5 cases were treated by conservative radiotherapy or chemotherapy due to their general conditions. The survival rate in the 21 cases treated by alternative chemoradiotherapy was 86.6％ at 2 years and 67.8％ at 5 years on Kaplan-Meier analysis.
Key words :clinical results, alternating chemoradiotherapy, nasopharyngeal cancer