Vol.103 No.1 contentsPRACTICA OTO-RHINO-LARYNGOLOGICA
Vol. 103 No. 1 January 2010
The Efficacy of Tebipenem-pivoxil (TBPM-PI) for Acute Otitis Media
-Assessed with a Scoring System Based on the Severities of the
Symptoms and Tympanic Membrane Findings-
Noboru Yamanaka, Muneki Hotomi, Akihisa Togawa,
Shin Takei and Masamitsu Kouno
(Wakayama Medical University)
In recent years, high prevalence penicillin-resistant Streptococcus pnenumoniae (PRSP) strains and b-lactamase non-producing ampicillin-resistant Haemophilus influenzae (BLNAR) strains have been reported the treatment of acute otitis media (AOM) in children. Between September 2005 and March 2006, we performed a clinical efficacy study on Tebipenem-pivoxil (TBPM-PI) in children with acute otitis media.
We assessed the severity of disease by using a scoring system based on symptoms and tympanic membrane changes, and a clinical efficacy study was carried out using the improvement in the score results cross linked in a table together with symptoms and TM findings and the objective grading of the physician in charge.
16 patients were enrolled in this study, ages were from 0 to 5 years old, with a median age of 3.50 years. S. pneumoniae, H. influenzae, and M. catarrhalis were detected as causative bacteria. The doses of TBPM-PI administered to children with AOM were 4 mg/kg b.i.d (10 cases) or 6 mg/kg b.i.d (6 cases) for seven days. The overall efficacy rates of TBPM-PI for AOM according to the clinical efficacy judged by the scoring system and the grading of attending physicians were 90.5％ and 100％, respectively. The eradication rate of pathogens at the end of treatment was 4/4. Based on our results, the present study strongly suggested that TBPM-PI would be an effective antimicrobial agent against moderate to severe AOM. Moreover, the scoring system was very useful for the decision making regarding the appropriate treatment regimen of AOM.
Key words :TBPM-PI, acute otitis media, scoring system, PRSP, BLNAR