Vol.96 No.6 contentsPRACTICA OTO-RHINO-LARYNGOLOGICA
Vol. 96 No.6 June 2003
Effect of Lipo-Prostaglandin E1 on Sudden Deafness
Tsuneo Inoue, Shintaro Yamaguchi, Akiko Tokumaru,
Shigenori Ohde, Toshihiro Misu and Kensuke Watanabe
(Dokkyo University School of Medicine Koshigaya Hospital)
In this study we examined 310 patients with sudden deafness treated in our hospital between 1996 and 2001. Seventy-one patients were treated with steroid only (steroid group), 130 patients were treated with steroid and Lipo-PGE1 combined therapy (steroid-LipoPGE1 group) and 53 patients were treated with Lipo-PGE1 only (LipoPGE1 group).
The improvement rate was 39.4, 67.7 and 81.1％ in the steroid, steroid-LipoPGE1 and LipoPGE1 groups, respectively. The improvement rate was significantly higher in the steroid-LipoPGE1 and LipoPGE1 groups than in the steroid group (p＜0.01). No significant difference in improvement rate was noted between steroid-LipoPGE1 group and LipoPGE1 group (p＜0.05).
These results suggest that the improvement of blood flow in the inner ear may be very important and Lipo-PGE1 is effective in treating sudden deafness.
Key words : Lipo-PGE1, sudden deafness, steroid