Vol.96 No.8 contentsPRACTICA OTO-RHINO-LARYNGOLOGICA
Vol. 96 No.8 August 2003
A Case of Cutaneous Leiomyosarcoma of the Cheek
Tsutomu Ueda, Jun-ichi Hasegawa, Tomoyuki Ogawa, Shitau Hirata,
Katsuhiro Hirakawa and Koji Yajin
(Hiroshima University)
Leiomyosarcoma is a malignant neoplasm of smooth muscle origin that rarely occurs in external soft tissues of the head and neck region. We report a 61-year-old male with cutaneous leiomyosarcoma of the right cheek. The tumor, which had a rough surface, was 45×35 mm in size, roundish in shape and well movable from the underlying tissues but not from the skin. The consistency was hard and elastic without tenderness. The tumor was completely excised with a margin of 25 mm proximally. The defect of overlaying skin was reconstructed using a D-P flap. The tumor was composed of long spindle-shaped cells with blunting nuclei. Multinucleated giant cells and mitotic cells were also found. Immunohistochemical examinations showed that these cells were positive for anti a-smooth muscle actin antibody, but negative for S-100 protein, CD34, CD68 (Kp-1) and p53. A boxed-in appearance was observed by silver staining. This tumor was diagnosed as leiomyosarcoma by these findings. No local recurrence or distant metastasis were noted one year after the excision.
Key words : cutaneous leiomyosarcoma, cheek, immunohistochemistry