Vol.96 No.11 contentsPRACTICA OTO-RHINO-LARYNGOLOGICA
Vol. 96 No.11 November 2003
A Case Report of Granular Cell Tumor
in the Inferior Auricular Lesion
Kaoru Okumura, Tsuyoshi Kitanishi, Fumito Itoh and Hohmei Suga
(Hikone Municipal Hospital)
Granular cell tumor (GCT) is a relatively uncommon soft tissue tumor first described by Abrikossoff in 1926. In this report, we present one case of granular cell tumor in the inferior auricular region. A 54-year-old female complained of left subaural mass and enbloc resection was performed. Histopathological features of the specimen included proliferation of large, polygonal cells with an eosinophilic granular cytoplasm in the dermis and subcutaneous tissue. Immunohistochemically, the tumor cells were positive for S-100 protein, and this tumor is thought to derive from Schwann's cell. The boundary between the tumorous and non-tumorous part was indistinct since the tumor cells invaded into adjacent connective tissue. The treatment of choice is radical resection with clear surgical margins. To rule out late recurrences, patients should be followed by annual physical examinations.
Key words : granular cell tumor, S-100 protein, Schwann's cell