Vol.97 No.4 contentsPRACTICA OTO-RHINO-LARYNGOLOGICA
Vol. 97 No. 4 April 2004
Superselective Intraarterial Infusion Therapy
for Head and Neck Carcinomas
Hiroaki Nakatani, Shoichi Sawada, Taizo Takeda, Mitsuhiko
Nakahira,
Yozo Washizu, Kei Fukushima, Kazuhiro Yamakawa and Shuji Matsumoto
(Kochi Medical School)
Shunji Takeuchi
(Kochi Prefectural Hata Kenmin Hospital)
Kensaku Hasegawa and Hiroya Kitano
(Tottori University School of Medicine)
We report the results of superselective intraarterial cisplatin (CDDP) infusion therapy combined with irradiation for 23 patients, mainly advanced head and neck carcinoma. All patients received intraarterial CDDP infusions with intravenous sodium thiosulfate (STS) neutralization. CDDP infusion was performed by the Seldinger's technique in 16 patients and by the implanted intraarterial reservoir system in 7 patients. STS was also infused by the reservoir system implanted at the forearm in most patients.
An overall response was observed in 21 of the 23 (91.3％) patients. Complete and partial responses were achieved in 16 (69.6％) and 5 (21.7％) patients, respectively. There were no patients with worse than grade III complications. We concluded that superselective intraarterial infusion therapy with a high dose of CDDP and STS was very effective for the management of advanced head and neck carcinomas and we recommend the implantable reservoir system for both CDDP and STS administration as an easy and low-invasive method.
Key words : superselective intraarterial infusion therapy, head and neck carcinoma, CDDP, implantable reservoir system