Vol. 99  No. 11  November  2006

Immunohistochemical Features of Myoepithelioma 
and Myoepithelial Carcinoma

Yoichi Hasegawa, Kenji Hattori, Yoshihiro Uno and Suzuyo Okazaki
(Sumitomo Hospital)

  Myoepithelioma (ME) and myoepithelial carcinoma (MEC) are both rare salivary neoplasms. We report cases of ME and MEC. The ME case was a 36-year-old female complaining of a painless mass in the parotid gland present for four years. The MEC case was a 50-year-old male suffering from nasal obstruction caused by the recurrence of a previous pleomorphic adenoma which arose from the hard palate, extending to the nasal cavity. Both tumors were surgically removed. Histopathological examination demonstrated that both tumors consisted of spindle and plasmacytoid cells, and, in the MEC case, infiltrative growth and cytologic abnormalities. Immunohistochemical study revealed positive reactions for SMA, vimentin, S-100 protein, and CK-14 in both tumor cell types, and significantly higher expressions of p53 and Ki-67 in the MEC case.

Key words :
immunohistochemistry, myoepithelioma, myoepithelial carcinoma, salivary gland

第99巻11号 目次   Vol.99 No.11 contents