PRACTICA OTO-RHINO-LARYNGOLOGICA

Vol. 100  No. 6 June  2007

Two Cases of Invasive Aspergillus Sinusitis and 
Mastoiditis Successfully Treated with Voriconazole

Eiji Kondo and Yoshiaki Kitamura
(JA Kochi Hospital)

Osamu Jinnouchi, Shinichi Nakagawa and Noriaki Takeda
(University of Tokushima Faculty of Medicine)

Hironori Akizuki
(Tokushima Red Cross Hospital)

Izumi Yura
(Kagawa Children's Hospital)

Hideyuki Nakagawa
(Yashima General Hospital)

Nobuya Sano
(Tokushima University Hospital)

     We report two cases of invasive aspergillosis of the head and neck regions. One patient was a 56-year-old male with invasive aspergillus sinusitis. The other patient was a 14-year-old boy with aspergillus mastoiditis after bone-marrow transplantation. Both cases were inoperable because of vascular invasion by aspergillus, and treatment with antifungal agents was discontinued due to severe side effects. A novel triazole voriconazole (VRCZ) was then used for salvage therapy and successfully treated invasive aspergillosis in both cases. VRCZ is an effective and well tolerated agent to treat invasive aspergillosis of the head and neck regions.


Key words : invasive aspergillus sinusitis, voriconazole, invasive aspergillosis, aspergillus mastoiditis

第100巻6号　目次　  Vol.100 No.6 contents