Vol.100 No.12 contentsPRACTICA OTO-RHINO-LARYNGOLOGICA
Vol. 100 No. 12 December 2007
Two Cases of Invasive Aspergillosis of the Sphenoid
Sinus treated with Voriconazole
Daisuke Kawakita, Masayuki Kondo, Noriko Sahara and Masaru Hatano
(Toyohashi Municipal Hospital)
Shinichiro Oyama
(Nagoya Daini Red Cross Hospital)
Riho Yoshida
(Higashi Municipal Hospital of Nagoya Department)
Shingo Murakami
(Nagoya City University)
Invasive aspergillosisis of the sphenoid sinus easily causes severe complications due to the anatomical position of the sinus. Thus, invasive aspergillosis of the sphenoid sinus is known to have a poor prognosis. We report two cases showing good results following endoscopic sinus surgery and voriconazole treatment.
Case 1 was a 78-year-old male, and the chief complaint was ache in the left eye, decrease in the left eyesight with field of vision stricture. We performed endoscopic sphenoidectomy and administered Micafungin sodium, but the symptoms recurred. After changing to voriconazole, a good result was obtained.
Case 2 was an 80-year-old male, and the chief complaint was descensus of both eyelids and obstruction of ocular movement. We performed endoscopic sphenoidectomy and the voriconazole dosage. The patient have not been recurred yet.
With an early diagnosis, invasive aspergillosis of the sphenoid sinus can be treated by endoscopic sinus surgery and voriconazole therapy. Voriconazole may be to the first choice of anti-fungul drugs for invasive aspergillosis of sphenoid sinus.
Key words : invasive aspergillosis, sphenoid sinus, voriconazole