Vol.102 No.8 contentsPRACTICA OTO-RHINO-LARYNGOLOGICA
Vol. 102 No. 8 August 2009
Compliance with Medication in Patients with Meniere's Disease, Comparison between Two Preparations of Isosorbide (Oral-Dose Solution and Jelly)
Hiroko Kouda
(Tokyo Metropolitan Health and Medical Treatment Corporation Okubo Hospital)
Takuro Sumi
(Ohme Municipal General Hospital)
Atsunobu Tsunoda and Ken Kitamura
(Tokyo Medical and Dental University)
In patients with Meniere's disease, compliance with the physician's instructions regarding medication and the clinical efficacy of medication were compared between two isosorbide preparations (oral solution and jelly). Each subject took two preparations in a cross-over fashion. The jelly was significantly superior to the solution in terms of easier carriage and storage as well as simplicity of ingestion. When patients were stratified by history of isosorbide treatment and drugs taken first on this cross-over study, results did not differ significantly. Comparison of clinical efficacy between the two preparations did not demonstrate any significant inter-group differences in terms of severity of dizziness, pure tone threshold level, compliance during the study period, or amount of drug taken.
Key words :compliance with medication, Meniere's disease, clinical efficacy, oral isosorbide solution,
isosorbide jelly