Vol.95 No.6 contentsPRACTICA OTO-RHINO-LARYNGOLOGICA
Vol. 95 No. 6 June 2002
Ramatroban Produces Beneficial Effects in Nasal Symptoms
of Patients with Perennial Allergic Rhinitis When Used in
Combination with an Antihistamine
Shinichiro Narita, Makoto Kurose and Kazutoyo Kobayashi
(Hakodate Municipal Hospital)
Hideaki Shirasaki and Tetsuo Himi
(Sapporo Medical University)
We investigated the effects of combination therapy with thromboxane
A2 receptor antagonist
(TxA2 RA: Ramatroban) and an antihistamine (Clemastine Fumarate) in patients with perennial allergic rhinitis. There was no significant difference in the three groups: combination group (n＝20), the
TxA2
RA (only Ramatroban) group (n＝18) and the antihistamine (only Clemastine Fumarate) group (n＝9) in terms of global improvement rating. Improvement was significantly better in the combination group compared to that in the
TxA2
RA group two weeks after the start of administration (p＜0.05). Moreover, intranasal rhinoscopic findings showed the mean nasal secretion score was significantly decreased in both the combination and
TxA2
RA groups (p＜0.05).
These findings suggest that TxA2
(Ramatroban) in combination with an antihistamine has beneficial effects on rhinorrhea in patients with perennial allergic rhinitis.
Key words : Ramatroban, allergic rhinitis, combination, antihistamine, thromboxane A2