Vol.96 No.9 contentsPRACTICA OTO-RHINO-LARYNGOLOGICA
Vol. 96 No.9 September 2003
Inverted Nasal Papilloma Transformed into
Spindle Cell Carcinoma; A Case Report
Masahiro Kikuchi, Etsuo Yamamoto, Yosaku Shiomi,
Yoshiko Shiomi, Keizo Fujiwara and Futoshi Watanabe
(Kobe City General Hospital)
Papilloma in the nasal cavity is a histologically benign neoplasm. However, it exhibits frequent local recurrence and is often associated with malignancy. Therefore, it is recommended that it be treated as a malignant tumor. We report a case of inverted nasal papilloma with malignant change in a 57-year-old female. This patient had suffered from nasal obstruction on the left side since December 1997. She visited a neighboring ENT clinic and underwent an excision of nasal polyp, which was diagnosed as an inverted nasal papilloma in January 1998. She was advised to undergo extended surgical treatment, however, she left it untreated for almost four years. In February 2002, she visited us because of severe headache and underwent extended Denker's operation. Chemotherapy and radiation therapy were added because the tumor was proven to be an inverted papilloma with squamous cell carcinoma. Unexpectedly, a recurrence was found in the anterior part of the nasal cavity in August 2002, and a component of spindle cell carcinoma appeared in the recurrent tumor. She was treated again by chemotherapy followed by extended maxillectomy, however, bone metastasis was found in October 2002. Since then, her general condition showed rapid deterioration and she died in November 2002.
Key words : inverted nasal papilloma, malignant transformation, spindle cell carcinoma