Vol.97 No.9 contentsPRACTICA OTO-RHINO-LARYNGOLOGICA
Vol. 97 No.9 September 2004
A
Clinical Study of Azithromycin Hydrate for Acute Sinusitis
with Special Regard to Methods of Oral Administration
Keijiro Fukazawa, Sadamu Takayasu, Yoshiteru Hashimoto and Masafumi Sakagami
(Hyogo College of Medicine)
Megumi Fujii and Mieko Okunaka
(Meiwa Hospital)
Ayako Iwata
(Amagasaki Central Hospital)
Azithromycin hydrate (AZM) is a new macrolide antimicrobial. In this study, we evaluated the clinical efficacy of AZM for acute sinusitis. The patients were randomly divided into two groups. Twenty-five patients (Group A) were given a daily 500-mg oral dose of AZM for 3 days, and 26 patients (Group B) were given the same dose of AZM two times with a 1-week interval. The clinical efficacy rate was 85.2％ in Group A and 88％ in Group B, and there was no significant difference in the efficacy rates between these groups. These findings suggested that AZM was useful for the treatment of acute sinusitis and that a 500-mg oral dose of AZM for 3 days should be sufficient.
Key words : Azithromycin, acute sinusitis, oral administration, bacterial study