Vol.98 No.4 contentsPRACTICA OTO-RHINO-LARYNGOLOGICA
Vol. 98 No. 4 April 2005
A Case of MALT Lymphoma of the Larynx Occurring
Asynchronously in the Parotid Gland
Satoru Fukami, Hideki Hirabayashi, Yoshiyuki Tanigaito,
Hiroaki Kanaya, Mamiko Nakamura, Kazutaka Goto and Kohtaro Baba
(Dokkyo Medical School of Medicine)
MALT lymphoma is a low-grade malignant lymphoma arising from mucosa associated lymphoid tissue.
Primary MALT lymphoma in the larynx is very rare. We encountered a case of laryngeal MALT lymphoma that occurred asynchronously in the parotid gland. The patient was a 68-year-old woman with complaints of abnormal sensation in the pharyngolarynx. Laryngeal endoscopy showed pale and swollen lesion covered with smooth mucosa in both arytenoid regions. Since cervical CT/MRI examinations demonstrated abnormal findings in the lesions, we performed laryngeal biopsy. Histopathological examination showed clear non-neoplastic cells with marked infiltration by lymphocytes. One year later, discomfort developed in the left parotid region. Partial excision of the left parotid gland and re-biopsy of the larynx were performed.
Pathological diagnosis of the parotid gland was MALT lymphoma because of the marked infiltration of centrocyte-like cell (CCL) in the marginal zone, and multiple lymphoepithelial lesions. Laryngeal histology was also diagnosed as MALT lymphoma due to appearance of CCL infiltration into the submucosal tissue.
Key words : MALT lymphoma, larynx, parotid gland, centrocyte-like cell, lymphoepithelial lesion