Vol.100 No.11 contentsPRACTICA OTO-RHINO-LARYNGOLOGICA
Vol. 100 No. 11 November 2007
Clinical Usefulness of Prophylactic Treatment with Olopatadine Hydrochloride for Japanese Cedar Pollinosis in Ishikawa Prefecture
Takaki Miwa, Toshiaki Tsukatani, Naoki Uramoto, Tomokazu Yoshizaki,
Makoto Ito, Naohiro Wakisaka, Shinji Tatsutomi and Mitsuru Furukawa
(Kanazawa University)
Yoshinori Shimizu
(Keiju Medical Center)
Mizuki Hirose
(Tonami General Hospital)
Clinical usefulness of olopatadine hydrochloride was studied in 97 patients with cedar pollinosis in 2005. The subjects were divided into 2 groups based on the time of starting treatment before or after the onset of pollen season. Subjective symptoms, objective findings of nose and quality of life scores using Japanese Rhino-conjunctivitis Quality of Life Questionnaire (JRQLQ No 1) were compared between the two groups. Both the clinical scores and QOL scores remained normal even at the peak of pollen scattering in patients who started medication before pollen season, and showed significant differences in each index compared with those in the patient group starting treatment after the onset of pollen season. The patients who started medication after pollen dispersal were not relieved of their symptoms at the peak of pollen scattering, but they had lower scores at both the beginning and end of pollen season. There were strong correlations between the clinical symptom scores and QOL scores in both groups. In conclusion, olopatadine hydrochloride appeared to be sufficiently effective for cedar pollinosis during the season of peak pollen of scattering by starting medication before the onset of pollen season.
Key words : prophylactic treatment, olopatadine hydrochloride, cedar pollonosis, Quality of Life